Directing the Immune System with Chemical Compounds

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• 作者：Rock J. Mancini ; Lalisa Stutts ; Keun Ah Ryu ; Janine K. Tom ; Aaron P. Esser-Kahn
• 刊名：ACS Chemical Biology
• 出版年：2014
• 出版时间：May 16, 2014
• 年：2014
• 卷：9
• 期：5
• 页码：1075-1085
• 全文大小：656K
• 年卷期：v.9,no.5(May 16, 2014)
• ISSN：1554-8937

文摘

Agonists of immune cell receptors direct innate and adaptive immunity. These agonists range in size and complexity from small molecules to large macromolecules. Here, agonists of a class of immune cell receptors known as the Toll-like receptors (TLRs) are highlighted focusing on the distinctive molecular moieties that pertain to receptor binding and activation. How the structure and combined chemical signals translate into a variety of immune responses remain major questions in the field. In this structure-focused review, we outline potential areas where the tools of chemical biology could help decipher the emerging molecular codes that direct immune stimulation.