Direct Synthesis of Pentafluoroethyl Copper from Pentafluoropropionate as an Economical C2F5 Source: Application to Pentafluoroethylation of Arylboronic Acids and Aryl Bromides

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• 作者：Hiroki Serizawa ; Kohsuke Aikawa ; Koichi Mikami
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：July 3, 2014
• 年：2014
• 卷：16
• 期：13
• 页码：3456-3459
• 全文大小：290K
• ISSN：1523-7052

文摘

The direct synthesis of pentafluoroethyl copper (CuC₂F₅) from a cuprate reagent and ethyl pentafluoropropionate as one of the most economical and useful pentafluoroethyl sources was accomplished. The advantages of this method are; all the reagents employed are low-cost and operationally simple, and the CuC₂F₅ reagent is prepared in virtually quantitative yield. Furthermore, the CuC₂F₅ reagent prepared was successfully applied to two types of pentafluoroethylations with arylboronic acids and aryl bromides to provide the pentafluoroethylated aromatic products in good-to-excellent yields, including large scale operations.