Temperature, pH, and Glucose Responsive Gels via Simple Mixing of Boroxole- and Glyco-Based Polymers

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• 作者：Yohei Kotsuchibashi ; Roman Vincent C. Agustin ; Jin-Yong Lu ; Dennis G. Hall ; Ravin Narain
• 刊名：ACS Macro Letters
• 出版年：2013
• 出版时间：March 19, 2013
• 年：2013
• 卷：2
• 期：3
• 页码：260-264
• 全文大小：375K
• 年卷期：v.2,no.3(March 19, 2013)
• ISSN：2161-1653

文摘

Statistical copolymers of N-isopropylacrylamide (NIPAAm) and 5-methacrylamido-1,2-benzoxaborole (MAAmBo) have been synthesized by reversible addition鈥揻ragmentation chain transfer (RAFT) polymerization. The solution properties of the NIPAAm homopolymers and statistical copolymers were investigated and it was found that, besides temperature and pH, the statistical copolymers were also responsive to the presence of free glucose in solution. Furthermore, responsive hydrogels and nanogels were formed spontaneously by simply mixing the statistical copolymers of P(NIPAAm-st-MAAmBO)s and well-defined glycopolymers. These gels were found to have temperature, pH, and glucose responsive properties.