Poly(N-vinyl-2-pyrrolidone-co-vinyl alcohol), a Versatile Amphiphilic Polymeric Scaffold for Multivalent Probes
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- 作者：Pavel I. Kitov ; Yohei Kotsuchibashi ; Eugenia Paszkiewicz ; Dennis Wilhelm ; Ravin Narain ; David R. Bundle
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：October 18, 2013
- 年：2013
- 卷：15
- 期：20
- 页码：5190-5193
- 全文大小：296K
- 年卷期：v.15,no.20(October 18, 2013)
- ISSN：1523-7052
文摘
A convenient scaffold based on poly(N-vinyl-2-pyrrolidone-co-vinyl alcohol) is proposed for presenting ligands in multivalent format. This amphiphilic polymer supports synthesis of conjugates in both organic and aqueous media, permits enzymatic processing of the ligand precursor, and, finally, offers a choice of formats for evaluation of biological activity either as a soluble inhibitor or as a capture reagent after deposition on a hydrophobic surface or standard microtiter plates.