Sulfoximine Assisted Pd(II)-Catalyzed Bromination and Chlorination of Primary 尾-C(sp3)鈥揌 Bond
详细信息 查看全文
- 作者：Raja K. Rit ; M. Ramu Yadav ; Koushik Ghosh ; Majji Shankar ; Akhila K. Sahoo
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：October 17, 2014
- 年：2014
- 卷：16
- 期：20
- 页码：5258-5261
- 全文大小：456K
- ISSN：1523-7052
文摘
S-Methyl-S-2-pyridyl-sulfoximine (MPyS) directed bromination and chlorination of the 1掳-尾-C(sp3)鈥揌 bond of MPyS-N-amides is realized under the influence of N-Br/Cl-phthalimides and a Pd(II)-catalyst. The sequential halogenation and acetoxylation of 伪-dimethyl MPyS-N-amides constructs highly functionalized 伪-trisubstituted aliphatic acid derivatives. The MPyS directing group is cleaved from the halogenated products and recovered.