Synthesis of Enantiopure 3-Substituted Morpholines

详细信息    查看全文

• 作者：Jan Bornholdt ; Jakob Felding ; Jesper Langgaard Kristensen
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：November 5, 2010
• 年：2010
• 卷：75
• 期：21
• 页码：7454-7457
• 全文大小：699K
• 年卷期：v.75,no.21(November 5, 2010)
• ISSN：1520-6904

文摘

Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.