Enantioselective γ-Alkylation of α,β-Unsaturated Malonates and Ketoesters by a Sequential Ir-Catalyzed Asymmetric Allylic Alkylation/Cope Rearrangement
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- 作者：Wen-Bo Liu ; Noriko Okamoto ; Eric J. Alexy ; Allen Y. Hong ; Kristy Tran ; Brian M. Stoltz
- 刊名：Journal of the American Chemical Society
- 出版年：2016
- 出版时间：April 27, 2016
- 年：2016
- 卷：138
- 期：16
- 页码：5234-5237
- 全文大小：412K
- 年卷期：0
- ISSN：1520-5126
文摘
A catalytic, enantioselective γ-alkylation of α,β-unsaturated malonates and ketoesters is reported. This strategy entails a highly regio- and enantioselective iridium-catalyzed α-alkylation of an extended enolate, and a subsequent translocation of chirality to the γ-position via a Cope rearrangement.