Matrix Metalloproteinase-2 Inhibitors from Clinopodium chinense var. parviflorum

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• 作者：Toshihiro Murata ; Kenroh Sasaki ; Kumiko Sato ; Fumihiko Yoshizaki ; Haruna Yamada ; Hiromichi Mutoh ; Kaoru Umehara ; Toshio Miyase ; Tsutomu Warashina ; Hiroaki Aoshima ; Homare Tabata ; Kouichi Matsubara
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：August 28, 2009
• 年：2009
• 卷：72
• 期：8
• 页码：1379-1384
• 全文大小：133K
• 年卷期：v.72,no.8(August 28, 2009)
• ISSN：1520-6025

文摘

From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A−I (2−10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC₅₀ 3.26 μM).