Antiproliferative Prenylated Xanthones and Benzophenones from the Roots of Cudrania tricuspidata in HSC-T6 Cells

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• 作者：Yang Hee Jo ; Bora Shin ; Qing Liu ; Ki Yong Lee ; Dong-Chan Oh ; Bang Yeon Hwang ; Mi Kyeong Lee
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：November 26, 2014
• 年：2014
• 卷：77
• 期：11
• 页码：2361-2366
• 全文大小：330K
• ISSN：1520-6025

文摘

Four new prenylated xanthones, cudracuspixanthones A鈥揇 (1鈥?b>4), two new prenylated benzophenones, cudracuspiphenones A (5) and B (6), and 11 known xanthones (7鈥?b>17) were isolated from the roots of Cudrania tricuspidata. The absolute configurations of compounds 2鈥?b>4 were deduced by the comparison of the calculated optical rotation values with the measured data. Compounds 1, 5, and 6 showed moderate antiproliferative activity on HSC-T6 cells with IC₅₀ values of 9.7, 3.3, and 7.1 渭M, respectively. Compounds 2鈥?b>4, 10, and 14鈥?b>16 had weaker activity. Flow cytometric analysis suggested that compounds 1 and 5 inhibited HSC-T6 cell proliferation in part by inducing apoptosis.