Palladium-Catalyzed Carbonylative Sonogashira Coupling of Aryl Bromides Using Near Stoichiometric Carbon Monoxide

详细信息    查看全文

• 作者：Karoline T. Neumann ; Simon R. Laursen ; Anders T. Lindhardt ; Benny Bang-Andersen ; Troels Skrydstrup
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：April 18, 2014
• 年：2014
• 卷：16
• 期：8
• 页码：2216-2219
• 全文大小：284K
• 年卷期：v.16,no.8(April 18, 2014)
• ISSN：1523-7052

文摘

A general procedure for the palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides is reported, using near stoichiometric amounts of carbon monoxide. The method allows a broad substrate scope in moderate to excellent yields. The formed alkynone motive serves as a platform for synthesis of various heterocyclic structures, including pyrimidines. Furthermore, the presented strategy allows effective ¹³C labeling.