Palladium-Catalyzed Sequential Arylation and Allylic Alkylation of Highly Functionalized Ketones: A Concise Synthesis of Mesembrine

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• 作者：Yuanhong Zhao ; Yongyun Zhou ; Leilei Liang ; Xiaodong Yang ; Fengxiang Du ; Liang Li ; Hongbin Zhang
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：February 5, 2009
• 年：2009
• 卷：11
• 期：3
• 页码：555-558
• 全文大小：166K
• 年卷期：v.11,no.3(February 5, 2009)
• ISSN：1523-7052

文摘

An unprecedented palladium-catalyzed sequential procedure toward arylation and allylic alkylation of highly functionalized cyclohexenones was developed. This new protocol leads to useful building blocks containing a benzylic quaternary carbon in only one step. A concise total synthesis of mesembrine based on this procedure was achieved in only five steps with 22% overall yield.