Solid鈥揕iquid Phase Equilibrium and Phase Diagram for the Ternary Carbamazepine鈥揝uccinic Acid鈥揈thanol or Acetone System at (298.15 and 308.15) K
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- 作者：Shenmin Xu ; Leping Dang ; Hongyuan Wei
- 刊名：Journal of Chemical & Engineering Data
- 出版年：2011
- 出版时间：June 9, 2011
- 年：2011
- 卷：56
- 期：6
- 页码：2746-2750
- 全文大小：733K
- 年卷期：v.56,no.6(June 9, 2011)
- ISSN：1520-5134
文摘
In this work, the solubility of carbamazepine鈥搒uccinic acid cocrystals in ethanol and acetone were measured at (298.15 and 308.15) K at atmospheric pressure. The solubility product (Ksp) which reflects the strength of cocrystal solid-state interactions of carbamazepine (CBZ) and succinic acid (SUC) relative to interactions with the solvent was determined. The solubility data show that significant complexation occurs in some solutions, and the relevant constants are derived. The ternary phase diagrams for the system of CBZ-SUC-ethanol or acetone at (298.15 and 308.15) K, which can provide the theoretical basis for crystallization processes, are presented.