Iron-Promoted Cyclization/Halogenation of Alkynyl Diethyl Acetals

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• 作者：Tongyu Xu ; Zhengkun Yu ; Liandi Wang
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：May 21, 2009
• 年：2009
• 卷：11
• 期：10
• 页码：2113-2116
• 全文大小：184K
• 年卷期：v.11,no.10(May 21, 2009)
• ISSN：1523-7052

文摘

FeCl₃- and FeBr₃-promoted cyclization/halogenation of alkynyl diethyl acetals has been efficiently realized, selectively affording (E)-2-(1-halobenzylidene or alkylidene)-substituted five-membered carbo- and heterocycles which were then efficiently transformed to vinylarenes by Suzuki coupling. The present protocol has provided a new alternative route to vinylic C−Cl and C−Br bond formation.