FeCl3路6H2O-Catalyzed Alkenylation of Indoles with Aldehydes

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• 作者：Qin Yang ; Liandi Wang ; Tenglong Guo ; Zhengkun Yu
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：September 21, 2012
• 年：2012
• 卷：77
• 期：18
• 页码：8355-8361
• 全文大小：370K
• 年卷期：v.77,no.18(September 21, 2012)
• ISSN：1520-6904

文摘

FeCl₃路6H₂O-catalyzed efficient C3-alkenylation of indoles was realized through the condensation of aldehydes and indole derivatives in the presence of 2 equiv of ethanol at ambient temperature, forming 3-vinylindoles in up to 93% yields. Ethanol promoted formation of the desired products. An obvious solvent effect was observed, and bisindoles were identified as the reaction intermediates.