Oxepinochromenones, Furochromenone, and their Putative Precursors from the Endolichenic Fungus Coniochaeta sp.

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• 作者：Yinchao Wang ; Zhihui Zheng ; Shuchun Liu ; Hua Zhang ; Erwei Li ; Liangdong Guo ; Yongsheng Che
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：May 28, 2010
• 年：2010
• 卷：73
• 期：5
• 页码：920-924
• 全文大小：180K
• 年卷期：v.73,no.5(May 28, 2010)
• ISSN：1520-6025

文摘

Six new polyketides including four oxepinochromenones, conioxepinols A−D (1−4), one furochromenone, coniofurol A (5), and one xanthone, conioxanthone A (6), have been isolated from the crude extract of the endolichenic fungus Coniochaeta sp. The absolute configurations of C-7 in 1 and the 7,8-diol moiety in 3 were assigned using the modified Mosher’s and Snatzke’s method, respectively, whereas that of C-8 in 5 was deduced via the circular dichroism data of the [Rh₂(OCOCF₃)₄] complex. Compounds 2−4 showed modest cytotoxicity against a small panel of human tumor cell lines.