Tetramic Acids and Pyridone Alkaloids from the Endolichenic Fungus Tolypocladium cylindrosporum
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- 作者：Xiao-Bin Li ; Lin Li ; Rong-Xiu Zhu ; Wei Li ; Wen-Qiang Chang ; Lu-Lu Zhang ; Xiao-Ning Wang ; Zun-Tian Zhao ; Hong-Xiang Lou
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：September 25, 2015
- 年：2015
- 卷：78
- 期：9
- 页码：2155-2160
- 全文大小：360K
- ISSN：1520-6025
文摘
Three new tetramic acid derivatives, tolypocladenols A1, A2, and B (1鈥?b>3), a new pyridone alkaloid, tolypyridone A (4), and a new coumarin derivative, 3,8-dihydroxy-4-(4-hydroxyphenyl)-6-methylcoumarin (5), together with four known compounds (6鈥?b>9) were isolated from the endolichenic fungus Tolypocladium cylindrosporum, which inhabits the lichen Lethariella zahlbruckneri. Structures of these compounds were determined by comprehensive analysis of spectroscopic data and single-crystal X-ray diffraction determination. Bioassay of the isolated compounds found that pyridoxatin (7) was cytotoxic to human cancer cells by induction of G0/G1 cell cycle arrest and apoptosis.