Amide Oxygen-Assisted Palladium-Catalyzed Hydration of Alkynes

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• 作者：Zhenming Zhang ; Lihuan Wu ; Jianhua Liao ; Wanqing Wu ; Huanfeng Jiang ; Jianxiao Li ; Jiawei Li
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：80
• 期：15
• 页码：7594-7603
• 全文大小：559K
• ISSN：1520-6904

文摘

Herein, an amide oxygen-assisted palladium-catalyzed hydration reaction of alkynes is realized to prepare a series of o-acylacetanilide derivatives with high yield, and single regioselectivity under mild reaction conditions. This transformation is simple, practical, and can be performed on a gram scale. Evaluation of the mechanism shows that the reaction should involve an oxypalladation process, and the 1,3-oxazine compound is proven to be a key intermediate.