Unique Aggregation of Anthrax (Bacillus anthracis) Spores by Sugar-Coated Single-Walled Carbon Nanotubes

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• 作者：Haifang Wang ; Lingrong Gu ; Yi Lin ; Fushen Lu ; Mohammed J. Meziani ; Pengju G. Luo ; Wei Wang ; Li Cao ; Ya-Ping Sun
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：October 18, 2006
• 年：2006
• 卷：128
• 期：41
• 页码：13364 - 13365
• 全文大小：152K
• 年卷期：v.128,no.41(October 18, 2006)
• ISSN：1520-5126

文摘

There has been significant interest in the binding of anthrax spores by molecular species, but with only limited success. Proteins and more recently peptides were used. However, despite the known presence of carbohydrates on the spore surface, carbohydrate-carbohydrate interactions have hardly been explored likely because of the lack of required specific platform for synthetic carbohydrates. We report the successful use of single-walled carbon nanotubes as a truly unique scaffold for displaying multivalent monosaccharide ligands that bind effectively to anthrax spores with divalent cation mediation to cause significant spore aggregation. The work should have far-reaching implications in development of countermeasure technologies.