Application of β-(2-Chloroaroyl)thioacetanilide in Synthesis(III): An Efficient Three-Component Synthesis of Thiochromeno[2,3-b]pyridines Catalyzed by KF/Neutral Al2O3
详细信息 查看全文
- 作者：Lirong Wen ; Chen Ji ; Yafeng Li ; Ming Li
- 刊名：Journal of Combinatorial Chemistry
- 出版年：2009
- 出版时间：September 14, 2009
- 年：2009
- 卷：11
- 期：5
- 页码：799-805
- 全文大小：241K
- 年卷期：v.11,no.5(September 14, 2009)
- ISSN：1520-4774
文摘
A series of new functionalized thiochromeno[2,3-b]pyridine derivatives have been synthesized via a sequence of Knoevenagel condensation, Michael addition, cyclization, and intramolecular nucleophilic substitution, which is first catalyzed by KF/neutral Al2O3 cooperated with PEG 6000 under microwave irradiation. Experimental results indicated that among the catalysts tested, KF/ neutral Al2O3 with PEG 6000 exhibits the best catalytic activity, which leads to a substantial improvement in the overall yield and purity of the desired final products and significantly shorter reaction time.