Pd-Catalyzed Transfer of Difluorocarbene

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• 作者：Xiao-Yun Deng ; Jin-Hong Lin ; Ji-Chang Xiao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：18
• 期：17
• 页码：4384-4387
• 全文大小：419K
• 年卷期：0
• ISSN：1523-7052

文摘

The study of transition-metal difluorocarbene complex has long been a subject of active investigation, but the transition-metal-catalyzed transfer of difluorocarbene remains a significant challenge. The Pd-catalyzed transfer of difluorocarbene is described to realize the coupling reaction of boronic acids with difluorocarbene to give (difluoromethyl)arenes and -olefins. Mechanistic investigations reveal that the Pd═CF₂ complex is an important intermediate for this transformation. This complex is prone to trimerization without the presence of starting materials.