Cu(I)-Catalyzed Domino Reaction of 3-Cyclopropylideneprop-2-en-1-ones

详细信息    查看全文

• 作者：Maozhong Miao ; Jian Cao ; Jingjing Zhang ; Xian Huang ; Luling Wu
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：March 15, 2013
• 年：2013
• 卷：78
• 期：6
• 页码：2687-2692
• 全文大小：354K
• 年卷期：v.78,no.6(March 15, 2013)
• ISSN：1520-6904

文摘

CuCl-catalyzed cyclization鈥揹imerization reactions of 3-cyclopropylideneprop-2-en-1-ones provide an interesting route to benzofuran-7(3aH)-one derivatives with one highly strained three-membered ring and one four-membered ring via intramolecular cycloisomerization, sequential bimolecular [4 + 2] cycloaddition, opening of the oxa-bridge, and ring contraction. Furthermore, the reaction was monitored by NMR experiments to unveil some key intermediates.