Synthesis of Tetrafluorinated Aromatic Amino Acids with Distinct Signatures in 19F NMR

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• 作者：Luoheng Qin ; Christopher Sheridan ; Jianmin Gao
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 20, 2012
• 年：2012
• 卷：14
• 期：2
• 页码：528-531
• 全文大小：251K
• 年卷期：v.14,no.2(January 20, 2012)
• ISSN：1523-7052

文摘

Fluorinated amino acids serve as powerful tools in protein chemistry. We synthesized a series of para-substituted tetrafluorophenylalanines via the regioselective S_NAr chemistry of the commercially available pentafluorophenylalanine Boc-Z. These novel unnatural amino acids display distinct ¹⁹F NMR signatures, making them powerful tools for analyzing protein鈥搈embrane interactions with NMR spectroscopy.