A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Growth

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• 作者：Sarah E. Tully ; Ross Mabon ; Cristal I. Gama ; Sherry M. Tsai ; Xuewei Liu ; and Linda C. Hsieh-Wilson
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：June 30, 2004
• 年：2004
• 卷：126
• 期：25
• 页码：7736 - 7737
• 全文大小：107K
• 年卷期：v.126,no.25(June 30, 2004)
• ISSN：1520-5126

文摘

Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the growth and differentiation of neurons. These studies represent the first, direct investigations into the structure-activity relationships of chondroitin sulfate using homogeneous synthetic molecules and define a tetrasaccharide as a minimal motif required for activity.