Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of an o-Nitrobenzenesulfonyl Group

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• 作者：Akinori Kawanishi ; Chiyako Miyamoto ; Yuki Yabe ; Makoto Inai ; Tomohiro Asakawa ; Yoshitaka Hamashima ; Hironao Sajiki ; Toshiyuki Kan
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：March 15, 2013
• 年：2013
• 卷：15
• 期：6
• 页码：1306-1309
• 全文大小：241K
• 年卷期：v.15,no.6(March 15, 2013)
• ISSN：1523-7052

文摘

Chemoselective hydrogenation of unsaturated compounds bearing an o-nitrobenzenesulfonyl (Ns)-amide moiety, affording the corresponding saturated compounds, was accomplished efficiently without loss of the nitro group by using the Pd/MS3A catalyst and a H₂ balloon. Partial hydrogenation of alkynes bearing an Ns group to corresponding cis alkenes was achieved with the combination of the Pd/BN catalyst and an additive (diethylenetriamine or acetic acid).