Industry Perspectives on Process Analytical Technology: Tools and Applications in API Manufacturing
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- 作者：Shailendra Bordawekar ; Arani Chanda ; Adrian M. Daly ; Aaron W. Garrett ; John P. Higgins ; Mark A. LaPack ; Todd D. Maloney ; James Morgado ; Samrat Mukherjee ; John D. Orr ; George L. Reid ; III ; Bing-Shiou Yang ; Howard W. Ward ; II
- 刊名：Organic Process Research & Development
- 出版年：2015
- 出版时间：September 18, 2015
- 年：2015
- 卷：19
- 期：9
- 页码：1174-1185
- 全文大小：850K
- ISSN：1520-586X
文摘
The IQ Consortium reports on the current state of process analytical technology (PAT) for active pharmaceutical ingredient (API) manufacturing in branded pharmaceutical companies. The article describes the application of PAT in manufacturing and provides representative examples in four common pharmaceutical unit operations: reaction and workup, crystallization, drying, and milling.