Extending the Record of Bis-纬-pyrone Polypropionates from Marine Pulmonate Mollusks
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- 作者：Marianna Carbone ; M. Letizia Ciavatta ; Jian-Rong Wang ; Ilaria Cirillo ; V茅ronique Mathieu ; Robert Kiss ; Ernesto Mollo ; Yue-Wei Guo ; Margherita Gavagnin
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：November 22, 2013
- 年：2013
- 卷：76
- 期：11
- 页码：2065-2073
- 全文大小：338K
- 年卷期：v.76,no.11(November 22, 2013)
- ISSN：1520-6025
文摘
The isolation and structure elucidation of 10 unreported polypropionate metabolites (compounds 6鈥?b>15), structurally related to either ilikonapyrone (1) or onchidione (3), from two onchidiid pulmonate mollusk species are discussed. Structure elucidation was achieved by NMR spectroscopy and chemical correlation with model compounds. Evaluation of in vitro growth-inhibitory properties in human cancer cells was also carried out on some of the isolated polypropionates including previously reported onchidione metabolites.