Synthesis and Biological Evaluation of Heteroanalogues of Kotalanol and De-O-Sulfonated Kotalanol

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• 作者：Sankar Mohan ; Kumarasamy Jayakanthan ; Ravindranath Nasi ; Douglas A. Kuntz ; David R. Rose ; B. Mario Pinto
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：March 5, 2010
• 年：2010
• 卷：12
• 期：5
• 页码：1088-1091
• 全文大小：231K
• 年卷期：v.12,no.5(March 5, 2010)
• ISSN：1523-7052

文摘

The synthesis of nitrogen and selenium analogues of kotalanol and de-O-sulfonated kotalanol, naturally occurring sulfonium-ion glucosidase inhibitors isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against the N-terminal catalytic domain of human maltase glucoamylase (ntMGAM) are described.