Palladium-Catalyzed Carbonylation of Aryl Tosylates and Mesylates
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- 作者：Rachel H. Munday ; Joseph R. Martinelli ; Stephen L. Buchwald
- 刊名：Journal of the American Chemical Society
- 出版年：2008
- 出版时间：March 5, 2008
- 年：2008
- 卷：130
- 期：9
- 页码：2754 - 2755
- 全文大小：54K
- 年卷期：v.130,no.9(March 5, 2008)
- ISSN：1520-5126
文摘
A general protocol for the palladium-catalyzed carbonylation of aryl tosylates and mesylates to form esters has been developed using a catalyst system derived from Pd(OAc)2 and the bulky, bidentate dcpp ligand. The system operates under mild conditions: atmospheric CO pressure and temperatures of 80-110 
C. A broad substrate scope has been demonstrated allowing carbonylation of electron-rich, electron-poor, and heterocyclic tosylates and mesylates, and the reaction shows wide functional group tolerance.
C. A broad substrate scope has been demonstrated allowing carbonylation of electron-rich, electron-poor, and heterocyclic tosylates and mesylates, and the reaction shows wide functional group tolerance.