Molecular Recognition of ,-Unsaturated Carbonyl C
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- 作者：Susumu Saito ; Takashi Nagahara ; Masahito Shiozawa ; Masakazu Nakadai ; and Hisashi Yamamoto
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：May 21, 2003
- 年：2003
- 卷：125
- 期：20
- 页码：6200 - 6210
- 全文大小：446K
- 年卷期：v.125,no.20(May 21, 2003)
- ISSN：1520-5126
文摘
Various 
,
-unsaturated carbonyl compounds were coordinated with aluminum tris(2,6-diphenylphenoxide) (ATPH) to give the corresponding Lewis acid-base complexes in a distinctive coordinationfashion (selective coordination). ATPH recognizes carbonyl substrates and subsequently orients itself asit forms a stable complex through selective coordination with the carbonyl oxygen. Selective coordinationalso confers a conformational preference to each carbonyl compound under the steric and electronicinfluence of ATPH, which enables the vinylogous aldol reaction of ,-unsaturated carbonyl compounds togive the corresponding 
-aldol products with different regio- and stereoselectivities.
,-unsaturated carbonyl compounds were coordinated with aluminum tris(2,6-diphenylphenoxide) (ATPH) to give the corresponding Lewis acid-base complexes in a distinctive coordinationfashion (selective coordination). ATPH recognizes carbonyl substrates and subsequently orients itself asit forms a stable complex through selective coordination with the carbonyl oxygen. Selective coordinationalso confers a conformational preference to each carbonyl compound under the steric and electronicinfluence of ATPH, which enables the vinylogous aldol reaction of ,-unsaturated carbonyl compounds togive the corresponding -aldol products with different regio- and stereoselectivities.