Triterpene Glycosides of Siraitia grosvenori Inhibit Rat Intestinal Maltase and Suppress the Rise in Blood Glucose Level after a Single Oral Administration of Maltose in Rats

详细信息    查看全文

• 作者：Yasushi A. Suzuki ; Yuji Murata ; Hiroshi Inui ; Masaki Sugiura ; and Yoshihisa Nakano
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2005
• 出版时间：April 20, 2005
• 年：2005
• 卷：53
• 期：8
• 页码：2941 - 2946
• 全文大小：98K
• 年卷期：v.53,no.8(April 20, 2005)
• ISSN：1520-5118

文摘

The effect of the crude extract from Siraitia grosvenori Swingle (SG-ex) on the postprandial rise inblood glucose level was investigated. The increase in plasma glucose level in response to the oraladministration of maltose was significantly suppressed in rats when SG-ex was given orally 3 minbefore the maltose administration. There was, however, no effect when glucose was administeredinstead, suggesting that the antihyperglycemic effect of SG-ex is elicited by inhibition of maltase inthe small intestinal epithelium. In vitro, SG-ex inhibited rat small intestinal maltase. Similar effectswere also observed both in vivo and in vitro when the concentrate of the sweet elements (triterpeneglycosides) prepared from SG-ex was used. Furthermore, the main sweet element of SG-ex,mogroside V, and some minor elements such as mogroside IV, siamenoside I, and mogroside IIIalso exhibited maltase inhibitory effect with IC₅₀ values of 14, 12, 10, and 1.6 mM, respectively. Theseresults suggest that SG-ex exerts anti-hyperglycemic effects in rats by inhibiting maltase activity andthat these effects are at least partially exerted by its sweet elements, triterpene glycosides.Keywords: Siraitia grosvenori; maltase; glycoside; rat; hypoglycemic; postprandial blood glucose