Novel Distance Dependence of Diffusion Constants in Hyaluronan Aqueous Solution Resulting from Its Characteristic Nano-Microstructure
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- 作者：Akiko Masuda ; Kiminori Ushida ; Hiroyuki Koshino ; Koichi Yamashita ; and Thomas Kluge
- 刊名：Journal of the American Chemical Society
- 出版年：2001
- 出版时间：November 21, 2001
- 年：2001
- 卷：123
- 期：46
- 页码：11468 - 11471
- 全文大小：51K
- 年卷期：v.123,no.46(November 21, 2001)
- ISSN：1520-5126
文摘
Material transports in hyaluronan (HA) aqueous solution were investigated applying two differenttechniques, i.e., pulsed field gradient NMR (PFG-NMR) and photochemical quenching, to the measurementof diffusion constants to show a sharp contrast resulting from the difference of the spectroscopic observationtime while the same probe molecules were commonly used in two experiments. The value from PFG-NMRreflects the relatively long transport along which the majority of the molecules are retarded by the mesh structureof HA solution. In such inhomogeneous fluids, the observable diffusion constant should generally depend onthe observation time and, i.e., the averaged distance of diffusion. Quantitative discussion, which compares theobtained characteristic distance of diffusion with the pore size, clarifies the role of the nano-microstructure ofHA solution forming small pores surrounded by the polymer chain networks.