Super Silyl Group for a Sequential Diastereoselective Aldol-Polyhalomethyllithium Addition Reaction

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• 作者：Matthew B. Boxer ; Hisashi Yamamoto
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：February 7, 2008
• 年：2008
• 卷：10
• 期：3
• 页码：453 - 455
• 全文大小：68K
• 年卷期：v.10,no.3(February 7, 2008)
• ISSN：1523-7052

文摘

The super silyl group governs high diastereoselectivity and yields for a sequential aldol-polyhalomethyllithium addition reaction. This uniquesilyl group is necessary to obtain the diastereoselectivities associated with this sequential reaction, capable of generating two new stereocenters.-Polyhalomethylcarbinols are generated with the simple and inexpensive dihalomethanes and trihalomethanes.