An Enyne Cycloisomerization Approach to the Triple Reuptake Inhibitor GSK1360707F

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• 作者：Nicole M. Deschamps ; Vassil I. Elitzin ; Bing Liu ; Mark B. Mitchell ; Matthew J. Sharp ; Elie A. Tabet
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：January 21, 2011
• 年：2011
• 卷：76
• 期：2
• 页码：712-715
• 全文大小：713K
• 年卷期：v.76,no.2(January 21, 2011)
• ISSN：1520-6904

文摘

The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by either Pt(II) or Au(I). Key aspects of this work such as the choice of the nitrogen protecting group and initial enantioselectivity studies are discussed.