Polymeric Nanomaterials for Islet Targeting and Immunotherapeutic Delivery

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• 作者：Kaustabh Ghosh ; Mathumai Kanapathipillai ; Netanel Korin ; Jason R. McCarthy ; Donald E. Ingber
• 刊名：Nano Letters
• 出版年：2012
• 出版时间：January 11, 2012
• 年：2012
• 卷：12
• 期：1
• 页码：203-208
• 全文大小：355K
• 年卷期：v.12,no.1(January 11, 2012)
• ISSN：1530-6992

文摘

Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.

Keywords:

Diabetes; pancreatic islet; nanoparticle; drug delivery; vascular endothelium; inflammation; tissue targeting