Solubility of Sodium Cefotaxime in Different Solvents

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• 作者：Haitao Zhang ; Jingkang Wang ; Ying Chen ; Meijing Zhang
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2007
• 出版时间：May 2007
• 年：2007
• 卷：52
• 期：3
• 页码：982 - 985
• 全文大小：42K
• 年卷期：v.52,no.3(May 2007)
• ISSN：1520-5134

文摘

The dissolution of sodium cefotaxime in 15 solvents were investigated. Only five solvents (formamide, N,N-dimethylformamide, dimethyl sulfoxide, water, and N-methylpyrrolidone) showed good solvency for the solid.The solubilities of sodium cefotaxime in N,N-dimethylformamide, formamide, and N-methylpyrrolidone weredetermined between the temperature range from (278.15 to 308.15) K, in water they were measured between(278.15 and 303.15) K, and in dimethyl sulfoxide they were determined between (293.15 and 308.15) K. A lasermonitoring observation technique was used to determine the dissolution of the solid phase in a solid-liquidmixture. The solubilities of sodium cefotaxime in all solvents measured increase with temperature, and thesolubilities of sodium cefotaxime also depend on the polarity of the solvent to some extent. The experimentalsolubility data were correlated with a semiempirical equation.