Stucturally Diverse Sesquiterpenes Produced by a Chinese Tibet Fungus Stereum hirsutum and Their Cytotoxic and Immunosuppressant Activities

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• 作者：Qiu-Yue Qi ; Jin-Wei Ren ; Li-Wei Sun ; Lu-Wei He ; Li-Bao ; Wei Yue ; Qin-Miao Sun ; Yi-Jian Yao ; Wen-Bing Yin ; Hong-Wei Liu
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：June 19, 2015
• 年：2015
• 卷：17
• 期：12
• 页码：3098-3101
• 全文大小：268K
• ISSN：1523-7052

文摘

Two new heterodimeric sesquiterpenes, sterhirsutins C (1) and D (2), along with eight new sesquiterpenoid derivatives, sterhirsutins E鈥?L (3鈥?b>10), were isolated from the culture of Stereum hirsutum. The absolute configuration of 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possessed an unprecedented chemical skeleton with a 5/5/5/6/9/4 fused ring system. Compound 10 is the first sesquiterpene coupled with a xanthine moiety. Compounds 1鈥?b>10 showed cytotoxicity against K562 and HCT116 cell lines. Compound 9 induced autophagy in HeLa cells. Compound 5 inhibited the activation of IFN尾 promoter in Sendai virus infected cells.