Copper N-Heterocyclic Carbene Complexes As Active Catalysts for the Synthesis of 2-Substituted Oxazolines from Nitriles and Aminoalcohols

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• 作者：Michael Trose ; Fa茂ma Lazreg ; Mathieu Lesieur ; Catherine S. J. Cazin
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：October 16, 2015
• 年：2015
• 卷：80
• 期：20
• 页码：9910-9914
• 全文大小：364K
• ISSN：1520-6904

文摘

The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper鈥揘HC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than those of previously reported methods.