Mixed Periodic Mesoporous Organosilica Nanoparticles and Core鈥揝hell Systems, Application to in Vitro Two-Photon Imaging, Therapy, and Drug Delivery
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- 作者：Jonas Croissant ; Damien Salles ; Marie Maynadier ; Olivier Mongin ; Vincent Hugues ; Mireille Blanchard-Desce ; Xavier Catto毛n ; Michel Wong Chi Man ; Audrey Gallud ; Marcel Garcia ; Magali Gary-Bobo ; Laurence Raehm ; Jean-Olivier Durand
- 刊名：Chemistry of Materials
- 出版年：2014
- 出版时间：December 23, 2014
- 年：2014
- 卷：26
- 期：24
- 页码：7214-7220
- 全文大小：564K
- ISSN：1520-5002
文摘
In this work, we describe the synthesis of new Mixed Periodic Mesoporous Organosilica Nanoparticles (MPMO NPs), combining the co-condensation of a tetra-trialkoxysilylated two-photon photosensitizer with bis-(triethoxysilyl)phenylene or ethylene. Novel gold core-MPMO shell systems are also described. The MPMO NPs are analyzed and characterized by multiple techniques, and are very efficient for anti-cancer drug delivery combined with two-photon therapy in MCF-7 breast cancer cells, leading down to 76% cancer cell death. MPMO NPs are thus very promising for nanomedicine applications.