Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush
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- 作者：Michela Rosini ; Elena Simoni ; Manuela Bartolini ; Andrea Cavalli ; Luisa Ceccarini ; Nicoleta Pascu ; David W. McClymont ; Andrea Tarozzi ; Maria L. Bolognesi ; Anna Minarini ; Vincenzo Tumiatti ; Vincenza And
- 刊名：Journal of Medicinal Chemistry
- 出版年：2008
- 出版时间：August 14, 2008
- 年：2008
- 卷：51
- 期：15
- 页码：4381-4384
- 全文大小：151K
- 年卷期：v.51,no.15(August 14, 2008)
- ISSN：1520-4804
文摘
Alzheimer’s disease (AD) is a multifactorial syndrome with several target proteins contributing to its etiology. To confront AD, an innovative strategy is to design single chemical entities able to simultaneously modulate more than one target. Here, we present compounds that inhibit acetylcholinesterase and NMDA receptor activity. Furthermore, these compounds inhibit AChE-induced Aβ aggregation and display antioxidant properties, emerging as lead candidates for treating AD.