Transition-Metal-Free Synthesis of Ynones via Decarboxylative Alkynylation of 伪-Keto Acids under Mild Conditions

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• 作者：Peng-Fei Wang ; Yi-Si Feng ; Zhi-Fei Cheng ; Qiu-Min Wu ; Guang-Yu Wang ; Liang-Liang Liu ; Jian-Jun Dai ; Jun Xu ; Hua-Jian Xu
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：September 18, 2015
• 年：2015
• 卷：80
• 期：18
• 页码：9314-9320
• 全文大小：403K
• ISSN：1520-6904

文摘

A transition-metal-free synthetic method of various ynones via decarboxylative alkynylation of 伪-keto acids is described. The reaction is carried out under mild conditions and exhibits remarkable tolerance of functional groups. The mechanism of a radical process is proposed in the reaction.