Biological Activity of Mesoporous Dendrimer-Coated Titanium Dioxide: Insight on the Role of the Surface鈥揑nterface Composition and the Framework Crystallinity

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• 作者：Katarzyna Milowska ; Aneta Rybczy艅ska ; Joanna Mosiolek ; Joanna Durdyn ; Eligia M. Szewczyk ; Nadia Katir ; Younes Brahmi ; Jean-Pierre Majoral ; Mosto Bousmina ; Maria Bryszewska ; Abdelkrim El Kadib
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：September 16, 2015
• 年：2015
• 卷：7
• 期：36
• 页码：19994-20003
• 全文大小：682K
• ISSN：1944-8252

文摘

Hitherto, the field of nanomedicine has been overwhelmingly dominated by the use of mesoporous organosilicas compared to their metal oxide congeners. Despite their remarkable reactivity, titanium oxide-based materials have been seldom evaluated and little knowledge has been gained with respect to their 鈥渟tructure鈥揵iological activity鈥?relationship. Herein, a fruitful association of phosphorus dendrimers (both 鈥渁mmonium-terminated鈥?and 鈥減hosphonate-terminated鈥? and titanium dioxide has been performed by means of the sol鈥揼el process, resulting in mesoporous dendrimer-coated nanosized crystalline titanium dioxide. A similar organo-coating has been reproduced using single branch-mimicking dendrimers that allow isolation of an amorphous titanium dioxide. The impact of these materials on red blood cells was evaluated by studying cell hemolysis. Next, their cytotoxicity toward B14 Chinese fibroblasts and their antimicrobial activity were also investigated. Based on their variants (cationic versus anionic terminal groups and amorphous versus crystalline titanium dioxide phase), better understanding of the role of the surface鈥搃nterface composition and the nature of the framework has been gained. No noticeable discrimination was observed for amorphous and crystalline material. In contrast, hemolysis and cytotoxicity were found to be sensitive to the nature of the interface composition, with the ammonium-terminated dendrimer-coated titanium dioxide being the most hemolytic and cytotoxic material. This surface-functionalization opens the door for creating a new synergistic machineries mechanism at the cellular level and seems promising for tailoring the biological activity of nanosized organic鈥搃norganic hybrid materials.