Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin

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• 作者：Zhipu Luo ; Xiaoli Shi ; Qin Hu ; Bin Zhao ; Mingdong Huang
• 刊名：Chemical Research in Toxicology
• 出版年：2012
• 出版时间：May 21, 2012
• 年：2012
• 卷：25
• 期：5
• 页码：990-992
• 全文大小：260K
• 年卷期：v.25,no.5(May 21, 2012)
• ISSN：1520-5010

文摘

Perfluorooctane sulfonate (PFOS) is a man-made fluorosurfactant and globally persistent organic pollutant. PFOS is mainly distributed in blood with a long half-life for elimination. PFOS was found mainly bound to human serum albumin (HSA) in plasma, the most abundant protein in human blood plasma, which transports a variety of endogenous and exogenous ligands. However, the structural basis of such binding remains unclear. Here, we report the crystal structure of the HSA鈥揚FOS complex and show that PFOS binds to HSA at a molar ratio of 2:1. In addition, PFOS binding renders the HSA structure more compact. Our results provide a structural mechanism to understand the retention of surfactants in human serum.