Transition-Metal-Free Direct Alkylation of Aryl Tetrazoles via Intermolecular Oxidative C鈥揘 Formation

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• 作者：Liang Wang ; Kaiqiang Zhu ; Qun Chen ; Mingyang He
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：December 5, 2014
• 年：2014
• 卷：79
• 期：23
• 页码：11780-11786
• 全文大小：438K
• ISSN：1520-6904

文摘

A transition-metal-free synthetic approach for constructing alkylated aryl tetrazoles has been developed using n-Bu₄NI as the catalyst and t-BuOOH as the oxidant. It involves the direct C鈥揘 bond formation through sp³ C鈥揌 activation. A wide range of benzylic C鈥揌 substrates (or alkyl ethers) and aryl tetrazoles undergo this reaction smoothly to deliver the corresponding products in good yields.