Copper-Catalyzed Oxidative Coupling of Formamides with Salicylaldehydes: Synthesis of Carbamates in the Presence of a Sensitive Aldehyde Group

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• 作者：Balaji D. Barve ; Yang-Chang Wu ; Mohamed El-Shazly ; Da-Wei Chuang ; Yuan-Bin Cheng ; Jeh-Jeng Wang ; Fang-Rong Chang
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：April 4, 2014
• 年：2014
• 卷：79
• 期：7
• 页码：3206-3214
• 全文大小：403K
• 年卷期：v.79,no.7(April 4, 2014)
• ISSN：1520-6904

文摘

A diverse library of novel carbamates was synthesized utilizing copper-catalyzed oxidative C鈥揙 coupling of formamides and salicylaldehydes. Sensitive aldehyde groups remained intact in the presence of an oxidant and a transition-metal salt. Salicylaldehydes bearing electron-donating, electron-withdrawing, and halogen groups as well as 1-hydroxy-2-naphthaldehydes provided the desired carbamates in good to excellent yields.