Efficient Synthesis of Impurity-C of Antimigraine Agent Rizatriptan Benzoate

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• 作者：Chinmoy Pramanik ; Rahul Bhumkar ; Ganesh Karhade ; Pravinkumar Khairnar ; Narendra Kumar Tripathy ; Mukund K. Gurjar
• 刊名：Organic Process Research & Development
• 出版年：2012
• 出版时间：March 16, 2012
• 年：2012
• 卷：16
• 期：3
• 页码：507-511
• 全文大小：247K
• 年卷期：v.16,no.3(March 16, 2012)
• ISSN：1520-586X

文摘

During the commercial manufacturing of antimigraine drug Rizatriptan benzoate, several impurities are reported to be formed. This present work demonstrates a convergent and short synthesis of the most critical impurity (C) of Rizatriptan, [2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indole-2-yl)-N,N-dimethylethanamine (1)], recently reported in U.S. Pharmacopeia.