Rhenium-Catalyzed Addition of Carbonyl Compounds to the Carbon−Nitrogen Triple Bonds of Nitriles: α-C−H Activation of Carbonyl Compounds
详细信息 查看全文
- 作者：Hikaru Takaya ; Masatsugu Ito ; Shun-Ichi Murahashi
- 刊名：Journal of the American Chemical Society
- 出版年：2009
- 出版时间：August 12, 2009
- 年：2009
- 卷：131
- 期：31
- 页码：10824-10825
- 全文大小：147K
- 年卷期：v.131,no.31(August 12, 2009)
- ISSN：1520-5126
文摘
The ReH7(PPh3)2-catalyzed addition of carbonyl compounds to the carbon−nitrogen bond of nitriles proceeds efficiently and selectively to give the corresponding (Z)-enamines, which are important synthetic intermediates. The key step of the reaction is the chemoselective α-C−H activation of carbonyl compounds induced by the α-heteroatom effect in the presence of nitriles.