Multivalent Nanofibers of a Controlled Length: Regulation of Bacterial Cell Agglutination

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• 作者：Dong-Woo Lee ; Taehoon Kim ; Il-Soo Park ; Zhegang Huang ; Myongsoo Lee
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：September 12, 2012
• 年：2012
• 卷：134
• 期：36
• 页码：14722-14725
• 全文大小：329K
• 年卷期：v.134,no.36(September 12, 2012)
• ISSN：1520-5126

文摘

Control of the size and shape of molecular assemblies on the nanometer scale in aqueous solutions is very important for the regulation of biological functions. Among the well-defined supramolecular structures of organic amphiphiles, one-dimensional nanofibers have attracted much attention because of their potential applications in biocompatible materials. Although much progress has been made in the field of self-assembled nanofibers, the ability to control the fiber length remains limited. The approach for control of the fiber length presented herein overcomes this limitation through the coassembly of amphiphilic rod鈥揷oil molecules in which the crystallinity of the aromatic segment can be regulated by 蟺鈥撓€ stacking interactions. The introduction of carbohydrate segments into the fiber exterior endows the nanofibers with the ability to adhere to bacterial cells. Notably, the fiber length systematically regulates the agglutination and proliferation of bacterial cells exposed to these fibers.