Multicomponent Coupling Reaction Using Arynes: Synthesis of Xanthene Derivatives

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• 作者：Eito Yoshioka ; Masatoshi Nishimura ; Takashi Nakazawa ; Shigeru Kohtani ; Hideto Miyabe
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：August 21, 2015
• 年：2015
• 卷：80
• 期：16
• 页码：8464-8469
• 全文大小：463K
• ISSN：1520-6904

文摘

One-pot synthesis of xanthene derivatives was achieved by a route involving the cascade three-component coupling reaction of arynes with DMF and active methylenes followed by the S_N2鈥?reaction of three-component coupling products with thiols. The reactivity of three-component coupling products toward nucleophiles and the further conversion of oxygen heterocycles allowing facile incorporation of structural variety were studied.