Calcification of Intraocular Implant Lens Surfaces
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- 作者：Wenju Wu ; Xiangying Guan ; Ruikang Tang ; Daniel Hook ; Wenyan Yan ; George Grobe ; and George H. Nancollas
- 刊名：Langmuir
- 出版年：2004
- 出版时间：February 17, 2004
- 年：2004
- 卷：20
- 期：4
- 页码：1356 - 1361
- 全文大小：766K
- 年卷期：v.20,no.4(February 17, 2004)
- ISSN：1520-5827
文摘
Calcification of octacalcium phosphate [Ca8H2(PO4)6·5H2O, OCP] on differently packaged "Ultem" and"Surefold" intraocular implant lens surfaces has been studied in vitro in solutions supersaturated withrespect to OCP at pH = 7.10 and 37 
C. No mineral deposition was observed on the lenses packaged inUltem vials even after treatment with behenic acid, one of the fatty acids identified on explanted lenses.Following treatment with behenic acid, nucleation of OCP occurred on the lenses from Surefold vials,which incorporate silicone gaskets; induction periods preceding calcification were about 6 h. No mineralizationwas found on the lenses in vials with other gasket materials, including polytetrafluoroethylene, fluorocarbonelastomer, and polypropylene. The results of this study indicate that both silicone and fatty acids suchas behenic acid play important roles in inducing the in vivo calcification of OCP on IOL lenses; all of thelens treatment steps were necessary for nucleation induction.
C. No mineral deposition was observed on the lenses packaged inUltem vials even after treatment with behenic acid, one of the fatty acids identified on explanted lenses.Following treatment with behenic acid, nucleation of OCP occurred on the lenses from Surefold vials,which incorporate silicone gaskets; induction periods preceding calcification were about 6 h. No mineralizationwas found on the lenses in vials with other gasket materials, including polytetrafluoroethylene, fluorocarbonelastomer, and polypropylene. The results of this study indicate that both silicone and fatty acids suchas behenic acid play important roles in inducing the in vivo calcification of OCP on IOL lenses; all of thelens treatment steps were necessary for nucleation induction.