Synthesis and Structure of Cyclic Trisaccharide with Expanded Glycosidic Linkages

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• 作者：Krishnagopal Maiti ; Narayanaswamy Jayaraman
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：June 3, 2016
• 年：2016
• 卷：81
• 期：11
• 页码：4616-4622
• 全文大小：435K
• 年卷期：0
• ISSN：1520-6904

文摘

A new cyclic trisaccharide is synthesized by cycloglycosylation of a linear trisaccharide, modified with hydroxymethyl moiety at C4 of glucopyranose moiety. The cyclic trisaccharide possesses a rarely observed perfect trigonal symmetry in the P3 space group, in a narrow cone shape, and a brick-wall type arrangement of molecules in the solid state, and exhibits a significantly enhanced binding affinity to 1-aminoadamantane in aqueous solution.